Heinrich Nissen (born 3 April 1839 in Hadersleben; died 29 February 1912 in Bonn) was a German Ancient historian.
Heinrich Nissen studied in Kiel and Berlin under August Boeckh and Theodor Mommsen. After graduating, he travelled in Italy between 1863 and 1867. This research was later published as the major work Italischen Landeskunde (1883 and 1902). Nissen first taught as a professor in Strasbourg. 1884, he was elected as successor to Arnold Schaefers at University of Bonn. There, unlike his predecessor, he exclusively taught Ancient History. he also pioneered Epigraphic research - based upon his study during his years in Italy - and was dedicated to Roman provincial archaeology. He was a co-founder of the Reichs-Limes-Kommission.
He retired in Autumn 1911, succeeded by Ulrich Wilcken. After his death he was buried in the Poppelsdorfer Friedhof (Poppelsdorfer Cemetery).